I've finally done it, the Simpsons vs. the Griffins in an epic battle to the death. Well, maybe not. Here's how I see it:
Homer vs. Peter
Winner: Homer (I figured they were about even, so I just chose Homer because he's been on TV longer)
Marge vs. Lois
Winner: Lois (Marge is great but she can't kick butt like Lois)
Bart vs. Chris
Winner: Bart (Chris is fat and lazy, 'nuff said)
Lisa vs. Meg
Winner: Meg (Lisa is just a little girl)
Maggie vs. Stewie
Winner: Stewie (Stewie is a maniacle genius and Maggie is just an adorable baby, it's no contest)
So as much as I hate to admit, the cast of Family Guy would win (I'm a bigger fan of the Simpsons, but not by much).
Thanks everyone for all of the awesome comments! I still can't believe I made this almost 5 years ago.